解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3391
更新日期:2013-01-01 00:00:00
abstract::Translationally controlled tumour protein (TCTP) is implicated in growth regulation and cancer. Recently, human TCTP has been suggested to play a role in the DNA damage response by forming a complex with ataxia telangiectasia-mutated (ATM) kinase . However, the exact nature of this interaction and its roles in vivo re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3986
更新日期:2013-01-01 00:00:00
abstract::The non-deterministic nature of photon sources is a key limitation for single-photon quantum processors. Spatial multiplexing overcomes this by enhancing the heralded single-photon yield without enhancing the output noise. Here the intrinsic statistical limit of an individual source is surpassed by spatially multiplex...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3582
更新日期:2013-01-01 00:00:00
abstract::Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3422
更新日期:2013-01-01 00:00:00
abstract::A transparent coating that repels a wide variety of liquids, prevents staining, is capable of self-repair and is robust towards mechanical damage can have a broad technological impact, from solar cell coatings to self-cleaning optical devices. Here we employ colloidal templating to design transparent, nanoporous surfa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3176
更新日期:2013-01-01 00:00:00
abstract::Upon muscle injury, the high mobility group box 1 (HMGB1) protein is upregulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at the translational leve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3388
更新日期:2013-01-01 00:00:00
abstract::Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3654
更新日期:2013-01-01 00:00:00
abstract::Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3111
更新日期:2013-01-01 00:00:00
abstract::Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3574
更新日期:2013-01-01 00:00:00
abstract::Brain oscillations reflect pattern formation of cell assemblies' activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3032
更新日期:2013-01-01 00:00:00
abstract::The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2712
更新日期:2013-01-01 00:00:00
abstract::The Earth's sole active carbonatite volcano, Oldoinyo Lengai (Tanzania), is presently erupting unique natrocarbonatite lavas that are characterized by Na- and K-bearing magmatic carbonates of nyerereite [Na2Ca(CO3)2] and gregoryite [(Na2,K2,Ca)CO3]. Contrarily, the vast majority of older, plutonic carbonatite occurren...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3687
更新日期:2013-01-01 00:00:00
abstract::Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3569
更新日期:2013-01-01 00:00:00
abstract::The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3206
更新日期:2013-01-01 00:00:00
abstract::The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3207
更新日期:2013-01-01 00:00:00
abstract::The resting-state human brain networks underlie fundamental cognitive functions and consist of complex interactions among brain regions. However, the level of complexity of the resting-state networks has not been quantified, which has prevented comprehensive descriptions of the brain activity as an integrative system....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2388
更新日期:2013-01-01 00:00:00
abstract::Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2370
更新日期:2013-01-01 00:00:00
abstract::Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a ta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3619
更新日期:2013-01-01 00:00:00
abstract::Predicting and controlling quantum mechanical phenomena require knowledge of the system Hamiltonian. A detailed understanding of the quantum pathways used to construct the Hamiltonian is essential for deterministic control and improved performance of coherent control schemes. In complex systems, parameters characteriz...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2405
更新日期:2013-01-01 00:00:00
abstract::Mitochondria are essential cellular organelles for generation of energy and their dysfunction may cause diabetes, Parkinson's disease and multi-systemic failure marked by failure to thrive, gastrointestinal problems, lactic acidosis and early lethality. Disease-associated mitochondrial mutations often affect component...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3886
更新日期:2013-01-01 00:00:00
abstract::Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3953
更新日期:2013-01-01 00:00:00
abstract::Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3846
更新日期:2013-01-01 00:00:00
abstract::The power conversion efficiency of hybrid solid-state solar cells has more than doubled from 7 to 15% over the past year. This is largely as a result of the incorporation of organometallic trihalide perovskite absorbers into these devices. But, as promising as this development is, long-term operational stability is ju...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3885
更新日期:2013-01-01 00:00:00
abstract::One key route for controlling reaction selectivity in heterogeneous catalysis is to prepare catalysts that exhibit only specific types of sites required for desired product formation. Here we show that alkanethiolate self-assembled monolayers with varying surface densities can be used to tune selectivity to desired hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3448
更新日期:2013-01-01 00:00:00
abstract::Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3898
更新日期:2013-01-01 00:00:00
abstract::The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3133
更新日期:2013-01-01 00:00:00
abstract::The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3668
更新日期:2013-01-01 00:00:00
abstract::Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the ve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2840
更新日期:2013-01-01 00:00:00
abstract::MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3280
更新日期:2013-01-01 00:00:00
abstract::Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin-proteasome targets a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2791
更新日期:2013-01-01 00:00:00
abstract::Signal regulatory protein α (SIRPα), an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, is an essential negative regulator of leukocyte inflammatory responses. Here we report that SIRPα cytoplasmic signalling ITIMs in neutrophils are cleaved during active inflammation and that the loss of SI...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3436
更新日期:2013-01-01 00:00:00
abstract::Cell identity is specified in the early mammalian embryo by the generation of precursors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm. Here we identify Angiomotin as a key regulator of this process. We show that the loss of Angiomotin, together with Angiomotin-like 2, leads ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3251
更新日期:2013-01-01 00:00:00
abstract::Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3112
更新日期:2013-01-01 00:00:00
abstract::Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3432
更新日期:2013-01-01 00:00:00
abstract::The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala. We show that hypocretin-1 levels are maximal during positive emoti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2461
更新日期:2013-01-01 00:00:00
abstract::The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3096
更新日期:2013-01-01 00:00:00
abstract::Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO2 zeolite, silic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2564
更新日期:2013-01-01 00:00:00
abstract::Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3376
更新日期:2013-01-01 00:00:00
abstract::The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3467
更新日期:2013-01-01 00:00:00
abstract::Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2561
更新日期:2013-01-01 00:00:00